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KMID : 0939920150470040949
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대한암학회지
2015 Volume.47 No. 4 p.949 ~ p.953
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Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report
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Woo Hyun-Sun
Lee Kyoung-Hwa
Yoon Phill-Hoon
Kim Su-Ji
Park In-Keun
Kim Young-Saing
Ahn Hee-Kyung
Hong Jun-Shik
Shin Dong-Bok
Sym Sun-Jin
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Abstract
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Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.
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KEYWORD
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Oxaliplatin, Colorectal neoplasms, Thrombocytopenia, Neutropenia
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